Quit Stalling or You’ll Be Silenced

Quit Stalling or You’ll Be Silenced

The use of small RNAs to program gene regulation and genome defense necessitates ever-changing choices about the sequences used for small-RNA biogenesis. Dumesic et al. now reveal stalled spliceosomes as a trigger for small-RNA biogenesis in the pathogenic fungus Cryptococcus neoformans.

The Histone Minority Report the Variant Shall Not Be Silenced

In this issue of Cell, Meneghini et al. demonstrate that replacement of canonical histone H2A with the histone variant H2A.Z within euchromatin prevents silent chromatin proteins from migrating into regions of the chromosome that normally are transcriptionally active. Thus, this highly conserved histone variant is critical for defining chromatin domains.

Which method of teaching would be better cooperative or lecture?

Introduction: Most of the knowledge acquired through lecturing is forgotten rapidly. As dentistry is becoming a more complicated field of study and as new techniques are introduced, the use of modern educational approaches to promote lifelong learning becomes necessary. This study is to compare cooperative teaching method and lecture method in terms of their impact on students' learning and the...

Quit early, quit often.

Different Stroke Scales; Which Scale or Scales Should Be Use?

Background: There has been considerable development in the clinometric of stroke. But, researcher is concerned that some scales are too generic, inherently and the insight may not be provided. The current study was conducted to determine which scale or scales should be used in stroke survivors. Methods: We selected 67 studies which published between January 2010 and December 2018 from Up to d...